结合呼出气、影像及风险因素的肺癌早期诊断模型研究-生物医学工程专业论文.docxVIP

优秀毕业论文 精品参考文献资料 浙江大学硕士学位论文 浙江大学硕士学位论文 摘要 学判断肺癌的敏感性和特异性后，联合呼出气中筛选出的31种与肺癌高显著相 关VOCs和影像学信息、吸烟行为、性别、年龄等分别采用Logistic回归模型、 BP神经网络模型以及Fisher判别模型建立肺癌早期诊断模型，结果显示相比较 于单影像学判断，多因素诊断模型的确能有效的提高肺癌诊断率。 本论文初步研究了呼出气标识物结合影像学判断及人群风险因素的诊断模 型，为肺癌的早期二级预防提供了一种新的技术手段，我们希望随着这项研究的 不断深入，在不久的将来这些模型能应用于肺癌早期诊断和筛查。 关键词：肺癌，影像学，呼出气标识物，风险因素，诊断模型 万方数据 浙江大学硕士学位论文 浙江大学硕士学位论文 Abstrdet Abstract Lung cancer，which is the public enemy of all mankind，is by far the most commonly diagnosed well the leading cause of death globally．In recent years，the incidence of lung cancer in our country presents a trend of rapid growth．However，the natural features of easy metastases and difficult identification of early symptoms，resulting in a short window of treatment and a low cure rate of lung cancer．Therefore，for extending therapeutic window and improving the survival rate of patients，the early diagnosis of lung was particularly important． In this study,the volatile organic compounds(VOCs)in exhaled breath，which were related with lung cancer皿C)，were combined with cl inical imaging and LC risk factors to model the early diagnosis of LC．The main contents include： 1)Design and implementation of detective hardware platforms and processes：the VOCs in exhaled breath of 149 cases of normal healthy people，27 patients with benign hmg diseases and 60 patients with LC were collected by the gas extraction apparatus and analyzed by TD-GC-MS，The assessment questionnaire of lung cancer risk factors was designed，and a database which was based on the questionnaire information was established．Imaging information of participants involved in the study were analyzed，classified and recorded to the database．The paper also studied the exhaled collection process，the sample pretreatment process，the sample logistics process and the quality control process． 2)Design and implementation of the software about data analysis and interactive applications：The software of VOCs analyses，tbat were mainly to deal with the background of all breath samples a