乌司他丁对脓毒症患者肾损伤保护作用.docxVIP

《乌司他丁对脓毒症患者肾损伤的保护作用》 发布时间：2015-02-09 11:55所属分类： HYPERLINK /lunwenfanwen/yixuelunwen/20150209864.html \o 医学论文 医学论文浏览：16134次 　　[Abstract]?Objective?To?explore?the?protective?effects?of?Ulinastatin?for?the?septic?patients?with?renal?injury，?to?analyze?the?influence?on?the?prognosis?and?immune?function，?and?to?investigate?its?possible?mechanism，?and?provide?the?basis?for?clinical?therapy.?Methods?Forty?six?patients?with?sepsis?were?selected?in?the?Peoples?Hospital?of?Lishui?City?from?March?2010?to?February?2014.?They?were?randomly?divided?into?the?control?group?(22?cases)，?who?were?treated?with?conventional?treatment?and?nursing，?and?the?observation?group?(24?cases)?were?treated?with?Ulinastatin?on?the?basis?of?conventional?therapy.?The?blood?urea?nitrogen?(BUN)?and?serum?creatinine?(SCr)?and?Cystatin?C?(Cystatin?C)，?T?cell?subsets?were?evaluated，?the?serum?tumor?necrosis?factor-α?(TNF-α)?and?interleukin?-6?(IL-6)?level，?and?acute?physiology?and?chronic?health?evaluation?(APACHE?Ⅱ)?scores?before?and?after?treatment?were?detected.?Results?Cystatin，?C，?BUN?and?SCr?of?two?groups?after?treatment?were?obviously?lower?than?those?before?treatment，?the?differences?were?statistically?significant?(P??0.05).?Cystatin?C，?BUN?and?SCr?of?the?observation?group?after?treatment?were?(1.21±0.24)?mg/L，?(14.92±1.23)?mmol/L?and?(210.74±18.36)?μmol/L，?lower?than?the?control?group?after?treatment?[(1.57±0.16)?mg/L，?(16.12±1.04)?mmol/L?and?(254.33±23.82)?μmol/L]?(P??0.05).?Compared?to?before?treatment，?CD4+，?CD8+?and?CD4+/CD8+?of?two?groups，?the?differences?were?statistically?significant?(P??0.05).?CD4+?and?CD4+/CD8+?of?the?observation?group?after?treatment?was?(43.87±5.04)%?and?(1.82±0.29)，?higher?than?that?of?the?control?group?after?treatment?[(38.04±4.51)%?and?(1.30±0.37)]?(P??0.05).?CD8+?of?the?observation?group?after?treatment?was?(31.92±3.26)%，?lower?than?the?control?group?after?treatment?[(35.42±3.11)%]?(P??0.05).?TNF-α?and?IL-6?of?two?groups?after?treatment?compared?with?before?treatme