环境相关浓度下药物对大型蚤多代慢性毒性.pdf

2013,33(3) 538~545 China Environmental Science 1,2 1* 1 1 , , , (1., 210098 2. , 241000) (Daphnia Magna),,, 6 .0.8,8.0,80.0μg/L ,.200.0μg/L F3()F4 .900.0μg/L F3 F4 ,F3F4 F5 .6 ,M1 (),M2 M3 , . 3 , M2 M3 , .2.0μg/L 20.0μg/L 9.0μg/L 90.0μg/L 6 ,200.0μg/L 900.0μg/L ,,, .(MEC),3 . X171.5 A 2013 Multigenerational chronic effects of pharmaceuticals on Daphnia magna at environmentally relevant 1,2 1* 1 1 concentrations. YANG Xiao-fan , LU Guang-hua , LIU Jian-chao , YAN Zhen-hua (1.College of Environment, Hohai University, Nanjing 210098, China 2.College of Biological and Chemical Engineering, Anhui Polytechnic University, Wuhu 241000, China). China Environmental Science, 2013,33(3)538~545 Abstract Chronic toxicity over six consecutive generations of sulfamethoxazole, ofloxacin and ibuprofen were bioassayed on the cladoceran D. magna at environment related concentrations. Sulfamethoxazole did not exhibit obvious effects on endpoints of reproduction and growth at 0.8,8.0 and 80.0μg/L. Ofloxacin at 200μg/L could cause a significant decrease at the number of first reproduction in F3 (third generation of clone) and F4. For ibuprofen, the age of first reproduction delayed significantly in F3 and F4 and the offspring number decreased obviously in F3, F4 and F5 at 900.0μg/L. Pharmaceutical mixtures did not show obvious effects in M1 treatment (minimum concentration of pharmaceutical mixture), while delayed the age of first reproduction and decreased the number of offspring significantly in subsequent generations in M2 and M3 treatment, respectively. In comparison with single exposure, pharmaceutical mixtures intensified negative effects on the first reproduction time and the first offspr