三维组织化肝细胞模型反映非诺贝特的体内作用生物化工专业论文.docxVIP

浙江大学硕士学位论文A 浙江大学硕士学位论文 Abstract Hyperlipemia has become a common disease due to the greatly improved living condition． As hyperlipemia has been the major risk factor of atherosclerosis，people paid great attention to develop lipid—lowering drugs．Lipid metablism is mainly processed in liver where lipid lowering drugs regulate lipid metabolism and trigger hepatotoxicity．Therefore，liver is the focused organ to evualate the pharmacology and toxicity during the discovery process of lipid lowering drugs． As in vivo experiments on animals are often high cost and time-consuming，suitable in vitro models