中药白四附子和娑罗子的化学成分研究及白附子脑苷a的全合成-生药学专业毕业论文.docx

List List of abbreviations CI．MS Chemical Ionization Mass Spectrum COSY Correlation Spectroscopy DBU 1，8-Diazabicyclo[5，4，O]undec一7一ene DCC DicyclohexyIcarbodiimide D．Gal D—galactose D—GIu D—glucose D1BAL—H Diisobut，rlaluminium hydride DMAP 4一N．N—dimethylaminopyridine DMF N，N—dimethylformamide EI—MS Electron Impact Mass Spectrum ESI．MS Electron Spray Ionization Mass Spectrum FABMS Fast Atom Bombardment Source HMBC Heteronuclear Multiple Bond Connectivity by 2D Multiple—quantum Coherence HMPA Hexamethylphosphoramide HMQC 1H—Detected Heteronuclear Multiple—Quantum Coherence via Direct Coupling HOBt 1一Hydroxybenzotriazole HPLC High Performance Liquid Chromatography HR—MS High Resolution Mass Spectrum IR Infrared NMR Nuclear Magnetic Resonance PDC PDC Pyridinium Dichromate PrepHPLC Preparative High Performance Liquid Chro—— matography P。T§OH P—Toluenesulfonic acid Rt Retention time SI．MS Secondary Ion Mass Spectrum TLC Thin Layer Chromatography TrCl Triphenylmethyl choride TOF．MS Time of Flying Mass Spectrum List List of Tables Table 1．1 Some species of Typhonium genus used as 1 7 drugs and herbal drugs in China Table 1-2 Some cerebrosides found in natural resources 24 Table 1-3 Some catalyst used in the acylating reaction 34 Table 1—4 Some glycosyl．groups used in the glycosidation 3 5 Table 2-1 The Constituents isolated from Typhonium 43 giganteum En91． Table 2-2 NMR data for Typhonoside A(1)(500MHz for 52 1H and 125 MHz for 13C NMR in CsDsN) Table 2-3 NMR data for Typhonoside B(2)(500MHz for 54 1Hand 125MHzfor”CNMRinC5D5N) Table 2．4 NMR data for Typhonoside C(9)(500MHz for 56 1H and 125MHzfor 13CNMRinC5D5N) Table 2-5 NMR data for Typhonoside D(10)(500MHz for 61 1H and 125 MHz for 13C NMR in C5D5N) Table 2-6 The results of some chemical constituents 63 experiments Table 2-7 The constituents separated by Prep—HPLC 69 3 Table Table 2—8 The types of some cerebroside structures 8l Table 2．9 The experiment of anti—blood coagulation， 90 viscosity of blood and plasma vis