基于fMRI功能连接度分析正常人相关脑区在运动过程中参与程度.pdfVIP

756 2009 25 5 Chin J Med Imaging Technol, 2009, Vol 25, No 5 Connection of motor related cortices in normal subjects: a functional connectivity MR study 1* 1 1 2 A I Lin , ZH EN G Zuo-f eng , DA I J ian-p ing , ZH A N G H ui ( 1. Imaging Center of N euroscience, Beij ing iantan H osp ital, Beij ing Neurosurg ical Institute, Cap ital Medical Univ ersity , B eij ing 100050, China; 2. Institute of A utomation, Chinese A cademy of S ciences, Beij ing 100080, China) [Abstract] Objective T o observe the functional connect ivit y between M 1 and other motor cortices in task and rest condi- t ions, and to evaluate how these activations influence human motor performance Methods ix healthy volunt eers were re- cruited in t he study Each of t hem underw ent BOLD-fMRI examination w ith a 30T MRI scanner Task-activat ion fMRI and functional connectivity ( resting-state) MRI data w ere acquired The former one w as designed as a block task of bilateral hand tapping The data were analyzed by PM2 A small region of interest which show ed t he maximal task activation w as chosen in the task-activation fMRI maps as seed voxels The correlation coefficient ( expressed as Z score) betw een seed vox- els and all the voxels in the brain w as calculated, and the Z score w ere compared betw een the task and rest conditions The statistical met hods w ere rank sum test by P 115 Results For resting state, functional connectivit y M RI maps based on the seed voxels produced clusters of voxels in regions of bilateral MC, MA and ipsilateral PL while for task conditions, besides those regions, the ALC w as also included For correlation coefficie