T细胞活化的分子机制 2014硕士.pdfVIP

T细胞活化机制 何睿 ruihe@fudan.edu.cn 免疫学系 上海医学院 复旦大学 Based on the history of antigen encounter and the stage of T cell activation.  Naïve T cells  Mature T cells that have not previously encountered antigen;  Preferential migration to secondary lymphoid organs (lymph nodes), where they recognize antigen  Effector T cells  Activated T cells capable of performing the functions required to eliminate foreign antigens  Preferential migration to sites of infection or inflammation  Short-lived  Memory T cells  Long-lived, functionally silent cells;  Mount rapid secondary immune responses to the same antigen exposure  Heterogenous (central and effector) 外周淋巴器官内 抗原识别 应答诱导 T细胞扩增和分化 分化的细胞 进入循环 效应T细胞和其他白细 在外周效应T细胞 胞迁移到感染部位 遭遇抗原 效应T细胞活化 T细胞的效应功能 Activation of T cells changes the expression of several cell-surface molecules . Functional responses of T cells  Secretion of cytokines  Proliferation  Differentiation into effector T cells  Differentiation into memory T cells Secretion of cytokines  One of the earliest detectable