磁性粒子的功能化及分离黄连丹参中有效成分的研究药物分析学专业论文.docxVIP

ABSTRACTBy ABSTRACT By modifying its surface with various functional groups(such as _0H，．COOH，-NILE)，magnetic particles with good biocompatibility，low toxicity，reusability and easy operating have been widely used in many fields such as biomedicine，environment governing and separation engineering．Compared with the classical method of separation and extraction，the method based on magnetic particles is featured with simple operation，speediness，non-polluting and low cost，which attracts an increasing number of researchers’interests on applying the method to extract the active ingredient from plant．Therefore，synthesizing the functional magnetic particles that can extract the target components selectively has great prospects of application．This paper prepares to carry out three functional magnetic particles and study their capability in extracting the active ingredient in plant． The thesis iS divided into four sections： The first part of this paper summarized the advances in functional magnetic particle including their synthetic methods and applications in this section．The focal point is on its application in the field of biomedicine and extracting active ingredient in herbal medicine．Also，we compared the different methods of extracting active ingredients from plant． The second part synthesized the Fe304@S i02@Ti02 magnetic particles by the sol-gel method，then characterized it by Dynamic light scattering tester(Malvern ZEN 3690)，X—ray diffraction(D／max 2500 X)， Fourier transform infrared spectrometer and Vibrating sample ⅡI 万方数据 magnetometer(VSM magnetometer(VSM 74 1 0)．The electronegativity of the Fe304@Si02@Ti02 magnetic particles could be linked to change of pH． Therefore，by regulating pH，Fe304@Si02@}Ti02 magnetic particles can selectively adsorb four kinds of alkaloid in Coptchinenswhich are positively charged．To achieve the best effect of extraction and separation， we optimized the condition of pH of the feed solution，the extraction time， the amount of part