The Epothilones - Home UW Madison- Department of Chemistry：埃博霉素-家-威斯康星大学麦迪逊分校化学系.pptVIP

The Epothilones ;Epothiwhat?;Overview ;Overview;Outline;Discovery;Cytotoxicity;Comparison of IC50 Values [nM];Mode of Action;Epothilone B / Taxol Mode I;Epothilone B / Taxol Mode II;Formation of Microtubules;Stabilized Microtubules BlockMitosis;Epothilone Biosynthesis;Biosynthesis;Epothilone Gene Cluster;Post Assembly Line Epoxidation;Cloning and Heterologous Expression;Initial Synthetic Efforts;The Race is On;Retrosyntheses;Danishefsky’s Macroaldolization;Nicolaou’s Macrolactonization;Schinzer’s RCM ;Nicolaou’s RCM;Danishefsky’s RCM;Substituent Effects on RCM;Overall # of Steps / Yields;Summ