饮食和益生菌对婴幼儿菌群的影响.pptxVIP

Role of Diet and Probiotics on Microbiota of Young Kids饮食和益生菌对婴幼儿菌群的影响 ;Growing up is a challenge 成长伴随着各种挑战;Infant immune system develops in tight interaction with the intestinal microbiota 婴儿的免疫系统与肠道系统紧密结合;How can diet modify microbiota?饮食如何调节微生物？;Modulators of our microbiota composition人体微生物组成的调节器;Antibiotics are major determinant of microbiota development and composition in kids抗生素是儿童菌群的发展和组成的关键因素;Use of penicillin-type antibiotics was not associated with large functional or compositional changes in microbiota. 青霉素类抗生素的使用与大量微生物功能和组成的改变无关。 Abundance of Bifidobacterium and Bacteroidetes normalized within 12 months after macrolide course. Abundance of Collinsella, Lactobacillus and Anaerostipes +total richness and maturity of microbiota, remained reduced for up to 2 years after macrolide course. 双歧杆菌和拟杆菌的丰度在大环内酯服用的12个月内恢复正常，而柯林斯菌，乳酸杆菌和丁酸弧菌的总丰度以及微生物的成熟度在服用大环内酯后的两年内仍处于减少状态。 When antibiotics are used annually/more frequently, microbiota may not have time to recover and the antibiotic-associated microbiota composition may persist. 当抗生素使用越来越频繁，微生物菌群可能没有时间恢复，而且抗生素相关的微生物可能持续存在。 Dysbiosis of microbiota has been associated with Inflammatory Bowel Disease, Autism Spectrum Disorders, Obesity, Asthma and Allergies. 菌群失调与炎症性肠道疾病，自闭症谱系障碍，肥胖，哮喘和过敏有关。 ;Probiotics can balance disturbed microbiota – clinical evidence益生菌可以平衡肠道菌群紊乱— 临床证据;;L.GG treatment prevented many of penicillin associated changes in the microbiota such as the increase in E. coli and Haemophilus 鼠李糖乳杆菌Lactobacillus rhamonosus GG的使用阻止了青霉素相关性菌群改变，例如：大肠杆菌和嗜血杆菌的增长。 Macrolide-associated reduction in bifidobacteria was not prevented by L. GG consumption ? one lactobacillus strain alone is not sufficient to prevent the microbiota changes associated with all antibiotic types; different species may be efficacious in association with different types of antibiotics. 大环内酯引起的双歧杆菌减少并不能通过鼠李糖乳杆菌Lactobacillus rhamonosus GG的摄取来改变。 ?单株乳杆菌并不能有效阻止所有抗生素引起的微生物菌群的改变；不同种的微生物可能会更有效地应对不同种抗生素带 来的改变。