胆固醇酯水解酶与动脉粥样硬化.pdfVIP

656 ISSN 1007鄄3949 Chin J Arterioscler,Vol21,No7,2013 ·文献综述 · [文章编号]摇 1007鄄3949(2013)21鄄07鄄0656鄄07 胆固醇酯水解酶与动脉粥样硬化 霍晓川,关 宁,冯旭,王超,甄 为,罗俊生 (辽宁医学院附属第一医院,辽宁省锦州市 121001) [关键词]摇 胆固醇酯;摇 胆固醇酯水解酶;摇 动脉粥样硬化 [摘摇 要]摇 胆固醇酯以脂滴的方式存储在胞浆内是泡沫细胞的主要特点,也是动脉粥样硬化斑块发生发展的关键 因素。 只有游离胆固醇才能从细胞内外流到细胞外与胆固醇接受体结合,巨噬细胞内胆固醇酯代谢的第一步就是 “水解冶。 水解是游离胆固醇外流的限速步骤,该反应由中性胆固醇酯水解酶催化。 此外,胆固醇酯水解酶还调节 胆固醇逆转运,从而参与体内胆固醇的最终清除。 本综述旨在分析当前各种胆固醇酯水解酶的特点,阐述其参与 细胞胆固醇酯水解来调节动脉粥样硬化的作用,为进一步明确能够作为防治动脉粥样硬化形成靶点的水解酶提供 线索。 [中图分类号]摇 R5 [文献标识码]摇 A Cholesteryl Ester Hydrolase and Atherosclerosis HUOXiao鄄Chuan,GUAN Ning,FENGXu,WANG Chao,ZHEN Wei,and LUOJun鄄Sheng (The FirstAffiliated Hospital of Liaoning Medical College,Jinzhou,Liaoning 121001,China) [KEY WORDS]摇 Cholesteryl Ester;摇 Cholesteryl Ester Hydrolase;摇 Atherosclerosis [ABSTRACT]摇 Accumulation of cholesteryl ester (CE) stored as cytoplasmic lipid droplets isthe main characteristic of macrophagefoamcells. Itiscentraltothedevelopmentof atheroscleroticplaques. Sinceonlyunesterifiedorfreecholesterol (FC) can beeffluxedfromthecellstoextracellularcholesterolacceptors,hydrolysisof CEistheobligatoryfirst stepinCE mobilization from macrophages. This reaction,catalyzed by neutral cholesteryl ester hydrolase (CEH),isincreasingly be鄄 ing recognized as the rate鄄limiting step in FC efflux. CEH,therefore,regulatesthe process of reverse cholesterol transport and ultimate elimination of cholesterol from the body. Inthisreview,we discussedthe characteristicsof thevariouscandi鄄 dates recognized to date and examined their roles in hydrolyzing cellular CE and thus regulating atherogenesis. We aim to provide cluesfor using hydrolase as a therapeutic target for atherosclerosis. 摇 摇 心脑血管疾病是危害