hFgl22蛋白表达与不同临床类型肝病的关系.PDFVIP

·436 · doi 10.3969/j.issn. 1673-4254.2013.03.27 J South Med Univ, 2013, 33(3): 436-438 临床研究 临床研究 外周外周血单核细胞血单核细胞hFglhFgl22 蛋白表达与不同临床类型肝病的关系蛋白表达与不同临床类型肝病的关系 1 2 1 1 1 1 玉艳红 ，原彤彤 ，黄力毅 ，吴继周 ，李国坚 ，吴健林 1 2 广西医科大学第一附属医院感染性疾病科，广西 南宁 530021；滕州市中心人民医院感染性疾病科，山东 滕 州 277500 摘要：目的探讨人纤维介素蛋白-2 凝血酶原酶（hFgl2）在慢性乙型肝炎及肝癌患者外周血单核细胞中的表达及其与慢性乙型 肝炎病情严重程度之间的关系。方法测定慢性乙型肝炎轻、中、重度，慢性重型乙型肝炎，肝癌患者共78 例外周血单核细胞 hFgl2 蛋白的表达进行比较，并将其与配对患者谷丙转氨酶（ALT）、谷草转氨酶（AST）及总胆红素（TBiL）行相关分析。结果 hFgl2 蛋白可以表达于外周血单核细胞，在慢重肝组和肝癌组表达高于对照组和慢乙肝组，而慢重肝组表达高于肝癌组。慢乙 肝重度组hFgl2 蛋白的表达与其ALT、AST 及TBiL 成正相关。结论hFgl2 蛋白可以表达于外周血单核细胞并呈现随着肝病严 重程度增加而表达升高的趋势。 关键词：hFgl2 ；慢性乙型肝炎；肝癌；外周血单核细胞 hFgl2 protein expression in peripheral blood mononuclear cells in different clinical types of liver disease 1 2 1 1 1 1 YU Yanhong , YUAN Tongtong , HUANG Liyi , WU Jizhou , LI Guojian , WU Jianlin 1Department of Infectious Disease, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; 2Department of Infectious Disease, Tengzhou Central Peoples Hospital, Tengzhou 277500, China Abstract: Objective To detect hFgl2 expression in peripheral blood mononuclear cells in patients with chronic hepatitis B and liver cancer and explore its association with the severity of chronic hepatitis B. Methods The protein expression of hFgl2 in peripheral blood mononuclear cells was detected in 78 patients with chronic hepatitis B (including mild, moderate, or severe cases), chronic severe hepatitis, or liver cancer, with 20 healthy volunteers as controls. The data were analyzed in comparison with the patients alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL and) levels. Results hFgl2 protein expression was si