三七总皂甙对颅脑损伤后Ca2、CaM含量影响的实验研究.docxVIP

三七总皂貳对颅脑损伤后Ca2+、CaM含量影响的实验研究 The experimental study of the influence of c2 + and CaM content after total saponins was carried out Update date: 2010-11-13 han jinan yongqin zhou titian will be the king 【abstract 】 objective to discuss the effect of the c2 +, CaM con tent of c2 +, CaM content and the treatment effect of brain injury after brain injury. Methods the moisture content of the brain tissue was determined by means of dry wet method, and the method for the determination of Ca2 + and CaM con tent in blood and brain tissue was determined by the method of photometry and photometry. Analyze the influence of PNS on these indexes? Results PNS could significantly reduce the amount of Ca2 + and CaM in the blood and brain tissue after cranial injury and reduce the water content of the bra in tissue and the iwensi blue dye. Conclusion PNS can block the nerve cell calcium overload after brain injury, blocking Ca2 + - CaM compound formation, reduce bra in edema and the permeability of blood bra in barrier, for craniocerebral injury of brain protection. 【 keyword 】 the calcium of calcium of 3, 7 calcium changes brain injury Effect of Panax Notoginseng Saponins on the Change of Ca2 +, CaM Contents Following Brain Injury HAN youqin, KUANG Yongqin, ZHOU Hutian, et al. * Dept. Of Neurosurgery, 477th Hospital of the PLA, Xiangfan, 441003 [Abstract] Objective To study the effects of the panax notoginseng saponins (PNS) on the changes of Ca2+, CaM content and the brain protective effects after brain injury. Methods A model of local cerebral injury on rabbits was set up by a drop of 100 g weight at 20 cm height hitting on the left epi dura, then 100 mg/kg PNS was intravenously injected at 30 min and 12 h after brain injury. The contents of Ca2+, CaM in blood and brain tissue were measured by atonic absorption spectrometry and radioimmunoassay. Results PNS significant reduced Ca.2+, CaM contents both in blood and cerebral tissue (P0.01). Conclusions PNS can reduce Ca2+, CaM conte