双链RNA(dSRNA)佐剂比较——PICPICLCPICUPICKCA.pdfVIP

Open Journal of Nature Science 自然科学, 2015, 3(4), 127-136 Published Online November 2015 in Hans. /journal/ojns /10.12677/ojns.2015.34017 Comparison of dsRNA Adjuvants—PIC, PICLC, PIC12U and PICKCa® * Haixiang Lin , Lietao Li, Yi Zhang Beijing Yishengxingye Scinece and Technology Co. Ltd., Beijing th th th Received: Oct. 27 , 2015; accepted: Nov. 10 , 2015; published: Nov. 16 , 2015 Copyright © 2015 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract dsRNA adjuvants include PIC, PICLC, PIC12U (Trade name Ampligen) and PICKCa® (PIC-kanamycin- Cacl2). They are ligands of varied pattern recognition receptors TLR3, NOD, MAD-5 and RID-1. The melt points are 57˚Cfor PIC, 80˚Cfor PICKCa, 91˚Cfor PICLC respectively. Because of the degrada- tion of double stranded RNA in the serum of primates and above, The first two kinds of adjuvants have poor effects or severe side effect to the monkey and human. PIC12U was also denied by US FDA in 2012, while PICKCa overcomes shortcomings of PIC, PICLC and PIC12U and it is safe and ef- fective for monkey and human. Keywords dsRNA, Vaccine Adjuvant, PICKCa 双链RNA(dsRNA)佐剂的比较——PIC 、PICLC 、 PIC12U 、PICKCa® * 林海祥 ，李烈涛，张 译 北京依生兴业科技有限公司，北京 *通讯作者。 ® 文章引用: 林海祥, 李烈涛, 张译. 双链RNA(dsRNA)佐剂的比较——PIC、PICLC、PIC12U、PICKCa [J]. 自然科学, 2015, 3(4): 127-136. /10.12677/ojns.2015.34017 林海祥 等 收稿日期：2015年10月27 日；录用日期：2015年11月10 日；发布日期：2015年11月16 日 摘 要 双链RNA佐剂包括PIC、PICLC、PIC12U和皮卡(PICKCa®) ，是多种膜式