蝉花液态培养菌丝体对ICR小鼠及SD大鼠之急毒性探讨.pdfVIP

Hans Journal of Food and Nutrition Science 食品与营养科学, 2017, 6(2), 96-105 Published Online May 2017 in Hans. /journal/hjfns /10.12677/hjfns.2017.62010 A Acute Toxicity Study of Cordyceps cicadae Mycelium in ICR Mice and SD Rats 1 1 2 3 1,4,5,6* Minyi Lin , Juihsia Hsu , Jiajiu Wu , Chun-Han Shih , Chinchu Chen 1 Grape King Bio Ltd., Taoyuan Taiwan 2 Food Industry Research and Development Institute, Hsinchu Taiwan 3 Quest Pharmaceutical Services, Taipei Taiwan 4 Institute of Food Science and Technology, National Taiwan University, Taipei Taiwan 5 Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shin Chien University, Taipei Taiwan 6 Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan Taiwan th th th Received: May 8 , 2017; accepted: May 19 , 2017; published: May 26 , 2017 Abstract Cordyceps cicadae (C. cicadae) is a valuable traditional Chinese medicine. It exhibits a variety of biological functions, including vision improvement and protection of renal function. Because of the shortage of wild C. cicadae, artificial cultivation is an ideal alternation. The C. cicadae sample was collected from the mountain area of Taiwan and mass produced by submerged cultivation. This study was conducted to a single limit dose of acute toxicity assessment in ICR mice and SD rats. ICR mice were divided into four groups and were fed with RO water, 12 g/kg bw of freeze