夫西地酸钠治疗耐甲氧西林金黄色葡萄球菌骨科感染的疗效观察_秦娜.pdfVIP

* 秦 娜 (河南洛阳正骨医院临床药学室, 洛阳市 471000 ) R969.4 A 100 1-0408 (2009 )23-1792-03 目的:比较夫西地酸钠与万古霉素治疗耐甲氧西林金黄色葡萄球菌(M RSA )骨科感染的 床疗效。方法:86 例MRSA 感 染患者随机分为治疗组(46 例)与对照组(40 例),分别给予夫西地酸钠、万古霉素治疗,均采用静脉滴注给药。记录2 组的疗效、细 菌清除率及药品不良反应。结果:治疗组与对照组的总有效率分别为91.3 %、92.5% (P 0.05), 细菌清除率分别为8 7.0 %、 8 7.5%(P 0.05)。治疗组无明显不良反应发生,对照组不良反应发生率为7.5%。结论:夫西地酸钠治疗M RSA 骨科感染效果与 万古霉素相当,且其不良反应较少。 夫西地酸钠;耐甲氧西林金黄色葡萄球菌;万古霉素;疗效 Clinical Efficac of Sodium Fusidate for Ortho edic Patients Infected with Methicillin-resistant Sta h - y p p y lococcus Aureus QIN Na(De t.of Clinical Pharmac , Henan Luo an rtho edic Hos ital, Luo an 471000, China) p y y g p p y g ABSTRACT BJECTIVE:To evaluate the efficacy of Sodium Fusidate versus vancomycin for orthopedic patients infected with methicillin-resistant Staphylococcus aureus (M RSA ).METH DS:A total of 86 M RSA-infected patients were ran- = = domly assigned to receive Sodium Fusidate (trial group, n 46)or vancomycin (control group, n 40 )by iv gtt.T he clinical efficac , bacterial clearance rate, and adverse reactions of the two rou s were recorded.RESULTS :In the trial rou versus y g p g p the control rou , the total effective rate was 91.3 %vs.92.5% (P 0.05), the bacterial clearance rate was 87.0 %vs. g p 8 7.5% (P 0.05), and adverse dru reaction was none in the trial rou vs.7.5%of the control rou .C NCLUSI NS: g g p g p Sodium Fusidate is as effective as vancom cin but has fewer side effects for ortho edic atients infected wi