水凝胶在药物缓释中的应用.pdfVIP

Journal of Comparative Chemistry 比较化学, 2018, 2(3), 109-113 Published Online September 2018 in Hans. /journal/cc /10.12677/cc.2018.23013 The Application of Hydrogels in Drug Controlled Release Qinlin Zhu, Ying Li School of Chemistry and Chemical Engineering, Shandong University, Jinan Shandong th th st Received: Ju n. 15 , 2018; accepted: Ju l. 25 , 2018; published: Aug. 1 , 2018 Abstract We can minimize administration frequency and make drug consistence in blood steady by the ap- plication of drug sustained release. Hydrogels have excellent properties of biocompatibility and biodegradability, which are suitable vehicles for drug delivery systems. This paper not only de- scribed the advantages of hydrogels in drug controlled release, but also summarized the applica- tion of hydrogels prepared by different methods in drug controlled release. Beyond that, this pa- per described an innovative approach for the controlled release of hydrophobic drugs. Keywords Hydrogels, Controlled Release, Hyaluronic Acid, Surfactant, Chitosan 水凝胶在药物缓释中的应用 朱钦麟，李 英 山东大学，化学与化工学院，山东 济南 收稿日期：2018年6月15 日；录用日期：2018年7月25 日；发布日期：2018年8月1 日 摘 要 药物缓释剂可以减少病人的给药次数，还使病人体内药物浓度稳定，使患者易于耐受。水凝胶具有良好 的生物相容性和生物可降解性，适于作为药物缓释的药物载体。本文不仅阐述了水凝胶在药物控制释放 体系方面的优势，而且概述了不同制备方法对应水凝胶在药物缓释上的应用。除此之外，本文还阐述了 新型的水凝胶搭载疏水性药物的方法。 文章引用: 朱钦麟, 李英. 水凝胶在药物缓释中的应用[J]. 比较化学, 2018, 2(3): 109-113. DOI: 10.12677/cc.2018.23013 朱钦麟，李英 关键词 水凝胶，药物缓释，透明质酸，表面活性剂，壳聚糖 Copyright © 2018 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Open Access 1. 前言 一般的给药方式易导致人体内的药物浓度不稳定，上下波动较大，有时超过病