分子细胞生六物学前沿-博士.pptVIP

分子细胞生物学专题----转录延伸因子P-TEFb及其活性调控 生命科学学院 陈瑞川 Main Points Transcription process of eukaryotic gene. P-TEFb: functions and its Activity regulation Steps of class II gene transcription RNA polymerase II (Pol II) P-TEFb: composition and property Discovered in 1995. (positive transcription elongation factor b) A heterodimer of Cdk9 and cyclin T, including T1, T2a, T2b and Cyclin K. But 80% P-TEFb is CDK9/Cyclin T1. kinase, phosphorylates CTD of Pol II, DSIF and NELF. How does cell signaling control the disruption of the inactive complex? Control P-TEFb activity by calcium signaling pathway UV