双歧杆菌代谢母乳寡糖机制的研究进展-食品科学.PDF

※专题论述 Journal of Dairy Science and Technology 2017, Vol.40 No.6 38 双歧杆菌代谢母乳寡糖机制的研究进展 姜陈波，洪 青，杭 锋* （光明乳业股份有限公司乳业研究院，上海乳业生物工程技术研究中心，乳业生物技术国家重点实验室，上海 200436 ） 摘  要：母乳寡糖（human milk oligosaccharides ，HMO ）结构复杂，其能够选择性地促进母乳喂养婴儿肠道中益 生菌双歧杆菌的生长。婴儿肠道相关双歧杆菌具有糖苷酶等分子工具，使其能够代谢HMO ，且代谢过程具有菌株 特异性。本文总结了HMO 的结构特点，探讨了婴儿肠道相关双歧杆菌代谢HMO 的机制，重点分析了双歧杆菌代谢 HMO 的种内差异以及代谢过程涉及到的分子工具的研究进展。 关键词：双歧杆菌；母乳寡糖；代谢；糖苷水解酶 Advance in Understanding the Mechanism Underlying Bifidobacterial Metabolism of Human Milk Oligosaccharides * JIANG Chenbo, HONG Qing, HANG Feng (Shanghai Engineering Research Center of Dairy Biotechnology, State Key Laboratory of Dairy Biotechnology, Dairy Research Institute, Bright Dairy and Food Co. Ltd., Shanghai 200436, China) Abstract: Human milk oligosaccharides (HMO) have complex structures and selectively stimulate the growth of probiotic bifidobacteria in the intestine of breast-fed infants. Infant gut-associated bifidobacteria provide molecular tools to metabolize HMO with strain specificity, such as glycosyl hydrolases. This review summarizes the structure of HMO and the mechanism underlying HMO metabolism by infant gut-associated bifidobacteria. The focus of this review is on the current advances in the intraspecific differences in bifidobacterial HMO metabolism and the tools involved in the metabolic process. Key words: bifidobacteria; human milk oligosaccharides (HMO); metabolism; glycosyl hydrolase / DOI:10.15922 ki.jdst.2017.06.008 中图分类号：TS252.1 文献标志码：A 文章编号：1671-5187 （2017 ）06-0038-07 引文格式： , , . [J].