结核性脑膜炎脑脊液抗酸染色及细胞学分析-神经病学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要··········································································································1 英文摘要··········································································································3 英文缩写··········································································································6 研究论文 结核性脑膜炎脑脊液抗酸染色及细胞学分析 前言··········································································································7 材料与方法······························································································8 结果········································································································12 附图········································································································15 附表········································································································19 讨论········································································································22 结论········································································································27 参考文献································································································28 综述 结核性脑膜炎的诊进展······································································30 致谢················································································································49 个人简历········································································································50 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 结核性脑膜炎脑脊液抗酸染色及细胞学分析 摘 要 目的: 结核性脑膜炎(Tuberculous meningitis,TBM)简称结脑,是由结 核分枝杆菌感染脑脊髓膜引起的非化脓性炎性疾病,其发病隐匿,与其他 慢性中枢神经系统感染难以鉴别,缺乏快速、灵敏的诊断实验,导致诊断治 疗不及时,具有高死亡率及致残率。传统抗酸染色灵敏性报道不一,通常很 难超过 20%。改良抗酸染色是在传统抗酸染色的基础上做了以下改进:脑 脊液玻片离心法替代试管离心,在进行抗酸染色前对标本行破膜处理,其 灵敏性及特异性均可达 80%以上且可同时观察到细胞内结核杆菌,给结脑 的诊断带来新的希望。本文对抗酸确诊的 170 例结脑患者进行分析,旨在 探讨结核性脑膜炎患者脑脊液抗酸染色及细胞学特点。 方法: 回顾性分析 2012 年 12 月至 2015 年 12 月河北医科大学第二医 院 170 例临床诊断为结核性脑膜炎且改良抗酸染色呈阳性患