抑郁症模型研究进展.pdfVIP

Hindawi Publishing Corporation 顎爀 Scienti铿乧 World Journal Volume 2014, Article ID 179180, 9 pages /10.1155/2014/179180 Review Article New Onset of Dermatomyositis/Polymyositis during Anti-TNF-砘 Therapies: A Systematic Literature Review Alexandra Maria Giovanna Brunasso,1,2 Werner Aberer,1 and Cesare Massone1 1 Department of Dermatology, Medical University of Graz, Graz, Austria 2 Department of Dermatology and Venereology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria Correspondence should be addressed to Alexandra Maria Giovanna Brunasso; giovanna.brunasso@ Received 28 August 2013; Accepted 14 November 2013; Published 29 January 2014 ` Academic Editors: A. Brassard, M. K. Connolly, J. Dutz, and C. Frances Copyright 漏 2014 Alexandra Maria Giovanna Brunasso et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We performed a systematic search of databases from 1990 to 2013 to identify articles concerning the new onset of dermatomyosi- tis/polymyositis (DM/PM) in patients treated with anti-TNF-砘 therapy. We retrieved 13 publications describing 20 patients where the new onset of DM/PM ater anti-TNF-砘 therapy was recorded. 17 patients were afected by rheumatoid arthritis (RA), one by Crohn鈥檚 disease, one by ankylosing spondilytis, and one by seronegative arthritis. In 91% of the cases antinuclear autoantibodies were detected ater the introduction of anti-TNF-砘 therapy. In 6 patients antisynthetase antibodies were detected and other clinical indings as interstitial lung disease (ILD) were recorded. I