米氮平与度洛西汀对老年抑郁症失眠者的疗效及HT的影响.PDF

２０１８ ３ ３３ ２ ２４１ - １ ２ ３ ， ， （１ ．， １０００１０ ；２ ．， １０００５０ ；３ ．， １０００８８） ： ５-（５-HT） 。 １４０ ，，７０ 。 （HAMD）（PSQI），。 ５-HT。 ，２ HAMD（＜ ０ ．０１），２ （＜ ０ ．０１），４ ６ ２ （＞ ０ ．０５）；２ HAMD （＜ ０ ．０１），（＜ ０ ．０１）；２ PSQI （＜ ０ ．０１），２ ，４ ６ （＜ ０ ．０１）；２ ５-HT （＜ ０ ．０１），２ （＞ ０ ．０５）。 ２ （＞ ０ ．０５）。 ，，。 ：；；；； DOI：１０ ．３９６９／ ．issn．１００４-２４０７ ．２０１８ ．０２ ．０２５ j ：R９７１ ：A ：１００４-２４０７（２０１８）０２-０２４１-０４ - １ ２ ３ GAO Yan ，ZHAO Yaming ，MA Xin （１ ．Department of Neurology， Beijing Longfu Hospital，Beijing １０００１０ ，China； ２ ．Department of Neurology， Beijing Friendship Hospital Affiliated to Capital Medical University ，Beijing １０００５０ ，China； ３ ．Department of Neurology，Beijing Anding Hospital Affiliated to Capital Medical University ，Beijing １０００８８ ，China） ：ObectiveTo compare theclinicaleffects on the depressed elderly complaining of anhypnia between mirtazapine and du- j toxetineandtheir effectsonserum ５-hydroxytryptaphane（５-HT）levelandsleepquality ．Methods Thesubjectswereselectedfrom １４０ casesof patientswith seniledepression who complained of anhypnia admitted in our hospital ．The patients were divided into the mirtazapine group and dutoxetine group on the basis of random time table ，each group ７０ cases．The clinical effects of the ２ groupswereevaluated respectively by adopting Hamilton′sdepression scale （HAMD） and Pittsburgh sleep quality index （PSQI） beforeandafter treatment ．Theadverse reactionswere recorded ，and theperipheral blood was sampled before and after treatment to testthecontentof ５-HT ．ResultsThe HAMDscoresof bothgroupsatdifferent timesafter treatmentevidently declinedascom- paredwiththosebeforetreatment （＜ ０ ．０１）．The HAMD scoresof themirtazapinegroupwereremarkably lower thanthatof the dutoxetinegroup after ２ weeksof treatment （＜ ０ ．０１），butno big differencewasfoundbetweenthe ２ r