胶体二氧化硅固化银杏黄酮组分磷脂复合物的研究.PDF

·1078 · 中草药 Chinese Traditional and Herbal Drugs 第45 卷 第8 期 2014 年4 月 胶体二氧化硅固化银杏黄酮组分磷脂复合物的研究 1, 2 2 2 1, 2 1 1, 2* 夏海建 ，张振海 ，孙 娥 ，陈小云 ，万高星河 ，贾晓斌 1. 南京中医药大学附属中西医结合医院，江苏 南京 210028 2. 江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室，江苏 南京 210028 摘 要：目的 制备银杏黄酮组分磷脂复合物（GF-PC ），并利用胶体二氧化硅（CS ）对其进行固化。方法 以CS 为载体， 固化GF-PC 。采用差示扫描量热分析（DSC ）法、X 射线粉末衍射分析（XPRD ）法和扫描电镜（SEM ）法对所制备的磷脂 复合物和固化粉末进行物相表征，并考察其体外溶出和流动性。结果 DSC 和XPRD 图谱表明，GF 以无定形状态存在于固 化粉末中。体外溶出结果表明，固化粉末能够有效促进药物的溶出。结论 CS 固化GF-PC 的制备工艺简单、操作方便，在 提高自身流动性的同时能够显著改善其溶出性。 关键词：银杏黄酮组分；胶体二氧化硅；磷脂复合物；固化粉末；表征 中图分类号：R283.6 文献标志码：A 文章编号：0253 - 2670(2014)08 - 1078 - 05 DOI: 10.7501/j.issn.0253-2670.2014.08.008 Solidifying of ginkgo flavones phospholipid complex using colloidal silica 1, 2 2 2 1, 2 1 1, 2 XIA Hai-jian , ZHANG Zhen-hai , SUN E , CHEN Xiao-yun , WAN-GAO Xing-he , JIA Xiao-bin 1. Affiliated Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China 2. Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China Abstract: Objective To prepare ginkgo flavones phospholipid complex (GF-PC) and to solidify it using colloidal silica (CS). Methods CS was used as a carrier to solidify GF-PC. The structures of the phospholipid complex and solidified powder were also characterized by differential scanning calorimetry, X-ray diffractomer, and scanning electron microscope, and dissolution in vitro and fluidity were also investigated. Results The phase analysis indicated that ginkgo flavones existed in the phospholipid complex and solidified powder as amorphous state. Dissolution in vi