Nuclear-rceptors(核受体)).ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Toxic equivalency factors for PCDDs, PCDFs and PCBs: Eljarrat Barceló, Trends Anal. Chem.22: 655 Final concentration is expressed as ?Equivalents of TCDD“  (e.g. ng TEQ / kg = ng TCDD / kg) Biomarkers/bioanalytical methods for AhR toxicity in vivo: liver enlargement, reduction of thymus weight, wasting syndrome, reproductive and developmental disorders in vivo biomarkers: EROD activity, CYP 1A1 and 1B1 expression in vitro: EROD (ethoxyresorufin-O-deethylase activity)  in H4IIE rat he