课件：骨髓增生异常综合征.pptVIP

后面内容直接删除就行 资料可以编辑修改使用 资料可以编辑修改使用 主要经营：网络软件设计、图文设计制作、发布广告等 公司秉着以优质的服务对待每一位客户，做到让客户满意！ 致力于数据挖掘，合同简历、论文写作、PPT设计、计划书、策划案、学习课件、各类模板等方方面面，打造全网一站式需求 * * * * Application of immunophenotyping to MDS In additional to acquired morphologic functional, cytogenetic, and production abnormalities, marrow cells in MDS frequently demonstrate aberrant patterns of differentiation antigen expression and lineage-aberrant antigen expression. Flowcytometry (FCM) in MDS using a panel of antibodies similar to those for AL has demonstrated aberrant differentiation patterns in both myeloid and erythroid precursors and lineage-aberrant antigen expression in myeloid precursors in a large percentage of cases. This approach may provide additional information to confirm diagnosis of MDS in difficult cases and may possibly contribute to subclassification of MDS. However, evaluation of both myeloid and erythroid lineages for this purpose requires use of a large panel of antigens, and this approach has not yet gained widespread clinical use. If validate and simplified with improvements in flow technology, it may become a valuable adjunct for diagnosis and subclassification of MDS. Cytogenetic and molecular alterations in MDS The cytogenetic changes found in MDS are not unique. Both structural and numerical cytogenetic changes may occur. The most frequent chromosomal abnormalities in MDS involved deletions of chromosomes 5, 7, 11, 12, and 20 and/or trisomy 8. The incidence of chromosomal abnormalities is about 30%~50% in primary MDS and 80% in mutagen-related MDS. The latter often has complex changes that frequently involve deletions of chromosomes 5 and/or 7 or the long arms of these chromosomes. Relative percentage of various cytogenetic abnormalities in de novo myelodysplastic syndrome (MDS). Cytogenetic and molecular alterations in MDS Translocations are rare in MDS. MDS-related chromosomal deletions suggest that tumor suppressor genes or DNA repair genes are altered in this group of d