代谢炎症与肥胖相关研究进展-中国动脉硬化杂志.PDF

634 ISSN 1007鄄3949 Chin J Arterioscler,Vol23,No6,2015 ·文献综述 · [文章编号]摇 1007鄄3949(2015)23鄄06鄄0634鄄05 代谢炎症与肥胖相关研究进展 1,2 1 1 闫美玲 ,夏丽莎 摇 综述,胡长平 摇 审校 (1. 中南大学药学院药理学系,湖南省长沙市410078;2.天津市第一中心医院药学部,天津市300192) [关键词]摇 代谢炎症;摇 肥胖;摇 炎性细胞因子 [摘摇 要]摇 肥胖是能量代谢失衡所导致的体脂过度积聚,可引起动脉粥样硬化、胰岛素抵抗和血脂异常等多种代 谢综合征的发生。 肥胖本身是一种发生在脂肪组织的慢性炎症疾病,伴随着脂肪组织细胞内炎症信号通路的激 活、炎性细胞因子的释放和免疫细胞的浸润等病理改变。 脂肪组织释放的炎症介质也可进入循环系统而影响其他 组织器官功能,引起相关代谢综合征的发生。 因此,代谢炎症在肥胖中的发生机制是研究肥胖及其相关疾病的基 础,针对肥胖代谢炎症的治疗方法和新靶点的开发也将为肥胖及其相关代谢疾病的治疗带来新的思路。 [中图分类号]摇 R364.5 [文献标识码]摇 A Advance in Research on Metaflammation and Obesity 1,2 1 1 YAN Mei鄄Ling ,XIA Li鄄Sha ,and HU Chang鄄Ping (1.Department of Pharmacology,Schoolof PharmaceuticalSciences,CentralSouth University,Changsha,Hunan410078, China;2.Department of Pharmacy,Tianjin First Central Hospital,Tianjin300192,China) [KEY WORDS]摇 Metaflammation;摇 Obesity;摇 Inflammatory Cytokines [ABSTRACT]摇 Obesity is a common disease defined asa stateof excessbodyfat accumulationwhich stemsfrom energy imbalance.摇 Obesity is closely associated with varied metabolism syndromes,such as atherosclerosis,insulin resistance and dyslipidemia.摇 Obesity per se isa chronic inflammatory disease in adiposetissue,accompaniedwith activation of cel鄄 lular inflammatory signals,releaseof inflammatory cytokinesandinfiltrationof immunecells.摇 Theinflammatory mediators from adipose tissue may affect other tissues or organs via circulation system,thus induce the genesis of related metabolism syndrome.摇 Therefore the understanding of metaflammation and its mechanisms contributes to research on obesity and the r