《临床药理学》中国医科大学PPT-druginteraction-wy.pptVIP

* PK interactions - Metabolism Outcome of inhibition: Active Drugs: Resulting in an increased therapeutic effect and toxic effect E.g., cimetidine and warfarin Prodrugs: Resulting in a reduced the therapeutic effect E.g., tamoxifen and antidepressants (such as Paroxetine) * PK Interactions - Excretion Alterations of urine pH: result in changes of drug excretion due to altered passive reabsorption E.g., Phenobarbital + NaHCO3 Urine pH Increase the excretion Urine acidification Weak basic drugs: amitriptyline, antihistamines, aminophylline, chloroquine, imipramine, morphine, mecamylamine,