响应曲面法优化羟基苯氧基丙酸甲酯结晶工艺.pdfVIP

第1 页 DOI:10.14 135/j .cnki.1006-3080. 20180425001 响应曲面法优化2-(4-羟基苯氧基)丙酸甲酯结晶工艺 黄克骄， 贺理珀， 宋兴福， 于建国 （华东理工大学国家盐湖资源综合利用工程技术研究中心，上海200237 ） 摘要：现有的 2-(4-羟基苯氧基)丙酸甲酯产品质量与后续工艺需求有一定差距，如产品粒度小、粒度 分布不均匀等。本文利用工厂提供的原料，采用响应曲面中的central composite design (CCD)设计实验，分 析了搅拌速率、降温速率、晶种质量、陈化时间等因素对结晶产品的影响，研究了工艺参数之间交互影响， 确定了多因素下最优工艺操作条件，对优化产品进行了分析，可满足工艺需求。 关键词：2-(4-羟基苯氧基)丙酸甲酯；响应曲面法；结晶工艺 中图分类号： TQ457.2+1 文献标志码： A Optimization of Crystallization Process of Methyl -2- (4- Hydroxyphenoxy) Propionate Based on Response Surface Methodology HUANG Ke-jiao ， HE Li-po ， Song Xing-fu ， YU Jian-guo (National Engineering Research Center for Integrated Utilization of Salt Lake Resource, East China University of Science and Technology, Shanghai 200237, China) Abstract : Methyl-2-(4-hydroxyphenoxy) propionate is an important intermediate for the synthesis of aryloxyphenoxy propionate (APP) high efficiency herbicides. There is a certain gap between the existing products and the process demand, such as the particle size and the distribution of particle size. Central composite design (CCD), a kind of response surface methodology, was used to explore the effects of stirring rate, cooling rate, seeding quantity and aging time on the particle size of methyl-2-(4-hydroxyphenoxy) propionate and the coefficient of variation (C.V.) of methyl-2-(4-hydroxyphenoxy) propionate. Based on the regression analysis, regression equations related to response values and factors wer