2017—2018年鄂尔多斯市中心医院抗菌药物致不良反应分析.pdfVIP

·3396 · 现代药物与临床 Drugs Clinic 第 33 卷 第 12 期 2018 年 12 月 2017—2018 年鄂尔多斯市中心医院抗菌药物致不良反应分析 郝 朵，刘俊保* 鄂尔多斯市中心医院 药剂科，内蒙古 鄂尔多斯 017000 摘 要：目的 了解鄂尔多斯市中心医院抗菌药物致药品不良反应（ADR ）发生的特点和规律，为促进临床合理用药提供 参考。方法 收集 2017 年 1 月—2018 年 5 月鄂尔多斯市中心医院上报国家 ADR 监测中心的所有抗菌药物致 ADR 报告 270 例，对其患者的年龄、性别、给药途径、抗菌药物种类、ADR 累及器官/系统及处理情况等数据进行统计分析。结果 ADR 报告中男性多于女性；＜10 岁和＞60 岁患者 ADR 发生率较高，分别占 35.6%、29.6% ；静脉给药途径 ADR 发生率最高， 占95.6% ；引发ADR 最多的为头孢菌素类抗菌药物，占 36.8% ；ADR 主要累及皮肤及其附件和消化系统，分别占 47.7% 、 23.6% ；大部分患者ADR 给予对应处理预后较好；用药后 1 d 内发生ADR 最多，占 63.7% 。结论 临床中应合理使用抗菌 药物，对其潜在的不良反应加以重视，发现 ADR 后要及时处理，减少 ADR 造成的损害。 关键词：药品不良反应；抗菌药物；合理用药 中图分类号：R978.1 ；R969.3 文献标志码：A 文章编号：1674 - 5515(2018)12 - 3396 - 05 DOI: 10.7501/j.issn.1674-5515.2018.12.068 Analysis on adverse drug reactions of antimicrobial drugs in Erdos Central Hospital from 2017 to 2018 HAO Duo, LIU Jun-bao Department of Pharmacy, Erdos Central Hospital, Erdos 017000, China Abstract: Objective To investigate the characteristics and regulations of antimicrobial drugs inducing adverse drug reactions （ADR ） in Erdos Central Hospital, and to provide reference for promoting rational drug use. Methods ADR (270 cases) induced by antimicrobial drugs in Erdos Central Hospital from January 2017 to May 2018 were analyzed statistically according to patient’s age and gender, route of administration, the type of antimicrobial drugs, organs/systems involved in ADR, processing situation, etc. Results Among ADR reports, the male was more than the female. There were a large number of ADR in patients with the age below 10 years old and above 60 years old, accounting for 35.6% and 29.6%. The incidence of ADR induced by intravenous route was the highest, accounting for 95.6%. Most of ADR was caused by cephalosporins, accounting for 36.8%. Lesion of skin and its accessories and digestive system injury were the main ADR, accounting