中华雪胆有效成分及抗炎活性研究;浙江栽培浙贝母种质遗传多样性的AFLP分析.pdfVIP

温州医学院硕士论文 胞TNF—Q、IF一6表达降低。 结论：除去化合物4和化合物12，其余化合物是首次从中华雪胆中分离得到，它 们均属于齐墩果烷型三萜皂苷。3一O-月_沪吡喃葡萄糖醛酸一齐墩果酸一28一o．夕 _俨吡喃葡萄糖苷(化合物4)和3一o-(67一乙酯)一夕切呻比哺葡萄糖醛酸一齐 墩果酸-28—0一卢切呻比喃葡萄糖苷(化合物11)具有一定的抗炎活性。 关键词： 中华雪胆化学成分三萜皂苷抗炎活性 一4一 温州医学院硕士论文 on chemical and Studiesthe anti—inflammatory composition o ’ ·一· ● TT ●，弋 activities m爿emsleya．chensns岱Cogn． ABSTRACT rhizomesof chensnsis famoustraditional OBJECTIVE：The Hemsleya Cogn．are medicinesin areusedinthetreatmentof disc- HemsleyaCogn．，which inflammatory as andotherdiseases．Inorder asessuch bronchitis，bacillarydysentery,tuberculosis thechemical to themedicativechemical studieson corn— explore constituents，further ofH．chensnsis carriedoutinthis theanti—inflamma- position Cogn．were paper．Also of acid-28-O-fl-D- toryactivitycompound4(3一O-伊D-glucuropyranosyl—oleanolic compound11[3一O·(67一ethyl glucopyranoside)and oleanolic acid-28一O移D·glucopyranoside】wereinvestigated． METHODS：TheofrhizomesfromH．chensnsis soakedin70 drypowder Cogn．Was ％ethan01．Thentheextract vacuumdistillationWasconcentratedand through collectedasthetotleextract．Themethanolwasreelaimed．ThetotleextractWas mL at and dissolved、Vitll1500distilledwater60℃～70Cextracted