广州中心不同病种疗前AFP比较-第三军医大学学报.DOCVIP

间充质干细胞移植治疗终末期肝病前后血清甲胎球蛋白(AFP)的变化 陈建华，川北医学院药学院药理教研室 四川南充 637000 徐玉琴，哈尔滨211医院感染科 黑龙江省哈尔滨市 150030 杨晋辉，昆明医学院第二附属医院肝胆胰内科 云南昆明 650000 胡祥，深圳市北科细胞工程研究所 510080 【摘要】：目的　探讨间充质干细胞移植治疗终末期肝病前后AFP变化。方法　间充质干细胞移植治疗73例终末期肝病患者，其中包括失代偿期肝硬化患者45例，慢性重症肝炎5例，监测疗前和疗后一周、疗后一个月、两个月AFP的变化。结果　 治疗前与疗后的AFP比较，差别有统计学差异，P0.05，疗后一周AFP较疗前明显升高，其后降低，至两个月至正常水平。结论　肝硬化和重症肝炎时，肝脏受到损害，移植干细胞后，肝细胞特异的标志物AFP明显增加，表明MSC向肝细胞分化，肝脏功能得到一定修复。此后的随访中，也未发现肿瘤发生，AFP短暂升高与肿瘤发生无关，病人的临床症状和相关指标有所改善。 关键词： 间充质干细胞；移植；AFP The change of serum AFP during mesenchymal stem cell (MSC) transplantation in the treatment of end-stage liver disease [Abstract]: Objective To explore the changes of tumor markers of AFP before and after MSC transplantation in end-stage liver disease. Methods After MSC transplantation therapy in 73 patients with end stage liver disease which contained 45 decompensated hepatic cirrhosis and 5 chronic severe hepatitis. we monitor AFP changes before treatment and after one week, one month and two months. Results Compared with before treatment, There were significant differences after treatment, P0.05. AFP was significantly increased after treatment for one week, thereafter decreased, recovered to normal level after two months. Conclusion Liver damages severe such as Liver cirrhosis and severe hepatitis, after transplantation of stem cells, specific markers AFP for liver cells increased significantly which suggests that MSC differentiate to liver cell, the liver function is in repair. We found no tumor occurrence during follow-up. Transient AFP elevation was not related to the tumor occurrence. At the same time, clinical symptoms and related items of patients improved. Keywords: mesenchymal stem cell; transplantation; AFP 1资料和方法 1.1病例来源 收集昆明医学院第二附属医院肝病科间充质干细胞治疗肝硬化患者23例、哈尔滨211医院肝病科间充质干细胞治疗肝硬化患者45例，慢性重症肝炎5例，通过病史及临床症状、相关实验室检查确诊病例。年龄22～ 73岁( 46.74 ±11.01) 岁。 纳入标准: ①，所有病例诊断均符合《肝脏病和感染病诊疗指南2010》。②年龄18 ～ 75岁的男性或女性。③半年内没有使用过间充质干细胞治疗。④理解并签署知情同意书者。 排除标准: ①恶性肿瘤患者或血液系统疾病。②过敏体质、曾有对血制品过敏史。③孕妇、哺乳期妇女。④合并腹腔、肺部或其他系统感染。⑤心、肺、肾等重要