基于肾上腺素受体相关肺主宣发的藏象理论及药效-天津中草药杂志社.PDF

中草药 Chinese Traditional and Herbal Drugs 第44 卷 第9 期 2013 年5 月 ·1069 · ·专 论 · 基于肾上腺素受体相关肺主宣发的藏象理论及药效物质基础的 现代生物学思考 白 钢 南开大学药学院，药物化学生物学国家重点实验室，分子药物天津市重点实验室，天津 300071 摘 要：藏象理论认为“肺主气司呼吸，主宣发肃降”，如何将中医药理论与现代生理和病理学相结合，用现代科学诠释中 医药理论一直是被关注的焦点。研究发现“宣肺解表”药物中存在着与肾上腺素受体信号转导相关的药效物质；而肺主宣发 “宣散浊气、转输精微、宣发卫气、助心行血”的内涵又与肾上腺素受体调控的交感神经节后纤维所支配的效应器官的生理 功能相吻合。围绕“肺主宣发”与肾上腺素受体及其信号通路之间的关联性进行论述，通过对“宣肺解表”在现代生物学理 论上的演绎，旨在揭示其生理病理的分子机制与中药药效物质基础的具体关联，希望能更有效地发挥中医藏象理论对现代药 物研发的指导作用。同时通过深入研究肺主宣发的理论，对于应用中医治肺理论指导由于环境、气候、生活方式等改变而导 致的各种疑难疾患的防治以及临床治疗有着重要意义。 关键词：宣肺解表；肾上腺素受体；药效物质基础；分子作用机制；中医药 中图分类号：R283.3 文献标志码：A 文章编号：0253 - 2670(2013)09 - 1069 - 09 DOI: 10.7501/j.issn.0253-2670.2013.09.001 Modern biological thinking about visceral manifestation theory on lung governing ascent and pharmacodynamic substance based on adrenergic receptor BAI Gang Tianjin Key Laboratory of Molecular Drug Research, State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300071, China Abstract: Visceral manifestation theory is that lung dominates Qi, breath, and governs ascent and dispersion. How to combine the theory of traditional Chinese medicine (TCM) with the modern physiology and pathology in modern scientific interpretation has been the focus of attention. Previous study found that most of the ventilating lung and releasing exterior drugs contained the pharmacodynamic substance related to adrenergic receptor (AR) signal transduction. The connotation of “lung governing ascent”, such as controlling breath movement, transferring nutrients, spreading heat to regulate temperature, helping the heart to control blood circulation, coincided with the physiological function of the organ dominated by the AR-regulated sympathetic postganglionic fibers. Therefore