熔融法合成芳氧甲基苯并咪唑化合物MeltingSynthesisof2.PDF

2009 年第 29 卷 有 机 化 学 Vol. 29, 2009 第 11 期, 1825～1828 Chinese Journal of Organic Chemistry No. 11, 1825～1828 ·研究简报· 熔融法合成 2-芳氧甲基苯并咪唑化合物 李英俊*,a 刘丽军 a 靳 焜 b 王 巍 a 赵 楠 a 李丽娜 a 李春燕 a (a 辽宁师范大学化学化工学院 大连 116029) (b 大连理工大学精细化工国家重点实验室 大连 116012) 1 摘要 以邻苯二胺和芳氧基乙酸为原料, 采用熔融法合成出了 10 种 2-芳氧甲基苯并咪唑化合物, 并利用 IR 和 H NMR 对其结构进行了表征. 在熔融法的合成中, 两种原料物质的量之比 n(邻苯二胺) ∶n (芳氧乙酸) ＝1 ∶1.1, 反应温度 (180 ±5) ℃. 该合成方法具有操作简便、反应时间短、后处理容易、副产物少、产率较高、绿色环保等优点. 关键词 2-芳氧甲基苯并咪唑; 熔融法; 合成; 表征 Melting Synthesis of 2-Aryloxymethylbenzimidazoles Li, Yingjun*,a Liu, Lijuna Jin, Kunb Wang, Weia Zhao, Nana Li, Linaa Li, Chunyana (a College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029) (b State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012) Abstract Ten compounds of 2-aryloxymethylbenzimidazole were synthesized by the reaction of o-phenylenediamine with aryloxyacetic acids using a melting method, and structurally characterized by IR 1 and H NMR techniques. In this method, the molar ratio of o-phenylendiamine and aryloxyacetic acid is 1 ∶ 1.1, and the temperature of the reaction is (180±5) ℃. This method has the advantages of simple operation, short reaction time, easy purification, less by-products, moderate to high yields and green