棕色脂肪形成的内分泌及环境影响评价因素研究-医学信息.PDF

综述 学信息2019 年2 月第32 卷第4 期 Medical Information Feb. 2019 Vol. 32 No.4 窑综述窑 棕色脂肪形成的内分泌及环境影响因素研究 1 2 2 庄俐 张惠莉 张瑞霞 渊1.青海大学研究生院 青海 西宁 810000 曰 2.青海大学附属医院 青海 西宁 810000冤 摘要 本文主要研究白色脂肪棕色化的内分泌调控及影响棕色脂肪变化的环境因素的最新研究成果 为其在代谢疾病中的治疗 潜力提供证据遥 截至目前 对棕色脂肪的内分泌调控 低温及低氧环境暴露对棕色脂肪的影响 以及脂肪组织在高原上维持能 量尧代谢和热平衡的相互转化的研究依然较少遥 入地了解BAT 的潜在能力 能够更好地控制这些细胞 以改善系统能量代谢 和葡萄糖稳态 为对抗人类肥胖和相关代谢紊乱提供新的治疗策略遥 关键词 棕色脂肪曰内分泌调控曰脂肪代谢曰低氧环境曰低温环境 中图分类号 R589.2 文献标识码 A DOI:10.3969/j .issn.1006-1959.2019.04.014 文章编号 1006-1959渊2019冤04-0036-04 Study on Endocrine and Environmental Factors in Brown Fat Formation 1 2 2 ZHUANG Li ,ZHANG Hui-li ,ZHANG Rui-xia (1.Graduate School of Qinghai University,Xining 810000,Qinghai,China; 2.Affiliated Hospital of Qinghai University,Xining 810000,Qinghai,China) Abstract ：This article focuses on the latest research findings on endocrine regulation of white fat browning and environmental factors affecting brown fat changes, providing evidence for its therapeutic potential in metabolic diseases. Up to now, studies on the endocrine regulation of brown fat, the effects of low temperature and low oxygen exposure on brown fat, and the mutual transformation of adipose tissue to maintain energy, metabolism and heat balance on the plateau are still rare. A deep understanding of the potential of BAT allows for better control of these cells to improve systemic energy metabolism and glucose homeostasis, providing new therapeutic strategies for combating human obesity and related metabolic di