洁净区空气和污染控制-翻译.pptxVIP

Air and contamination control空气和污染控制Air and contamination control空气和污染控制Without air we cannot breathe, so as long as we require personnel to operate our processes we need an air supply.没有空气我们无法呼吸，所以只要我们需要人员操作我们的工艺，我们就需要空气供应。Even in clean rural areas air is contaminated with about 108 particles of 0.5μm and greater per m3, many of these will be microorganisms depending on the nature of the area and the season of the year – so air is a contamination problem即使在干净的农村地区，空气也被大约108颗每平方米0.5微米甚至更大的颗粒污染，其中许多是微生物，这取决于该地区的性质和一年中的季节 - 因此空气是一个污染问题However in the pharmaceutical industry air flow is the answer to many contamination problems然而，在制药工业中，空气流动是许多污染问题的答案So we are going to discuss this dual relationship of the pharmaceutical industry with air因此，我们将讨论制药业与空气的这种双重关系Air as a contamination source空气作为污染源Microorganisms do not grow and increase in numbers in air微生物不会在空气中生长和增加Most microorganisms find it hard to survive in air because the environment is so desiccating and because of the exposure to UV radiation.大多数微生物发现它难以在空气中存活，因为环境是如此干燥并且因为暴露于紫外线辐射Survival often depends on being carried on “rafts” of physical matter, such as skin flakes.生存通常取决于携带物理物质的“筏”，例如皮屑。Typical airborne microorganisms are spores of the genus Bacillus and related genera, and Micrococcus or Staphylococcus.典型的空气传播微生物是芽孢杆菌属和相关属的孢子，以及微球菌或葡萄球菌。Controlling airborne contamination in cleanrooms控制洁净室中的空气污染There are four principle applying to control of air-borne microorganisms in clean rooms. 控制洁净室中的空气传播微生物有四个原则。Filtration过滤Dilution稀释Directional Air Flow定向气流Air Movement空气运动I will address each one separatelyFiltrationFiltration removes microorganisms:过滤去除微生物：HEPA (high efficiency particulate air) filters remove up to about 99.997% of particles from airHEPA（高效微粒空气）过滤器可从空气中去除高达约99.997％的颗粒HEPA Filters are protected from blockage by pre-filters which remove up to about 90% of particles from airHEPA过滤器通过预过滤器防止堵塞，预过滤器可从空气中去除多达约90％的颗粒Therefore if air contains about 3 x 108 particles per m3, and you have one pre-filter and one