吡咯里西啶生物碱性肝损伤研究进展-传染病信息.PDF

传染病信息  2017年8月30日  第30卷  第4期  Infect Dis Info, Vol. 30, No. 4, August 30, 2017  ·209· 吡咯里西啶生物碱性肝损伤研究进展 文良志，孙文静，刘凯军，王　斌，魏艳玲，陈东风，崔红利     [摘要]　在我国，传统中药的不合理使用是药物性肝损伤最常见的原因。近年来，土三七等传统中药所致肝窦阻塞综 hepatic sinusoidal obstruction syndrome, HSOS pyrrolizidine 合征（ ）的发病率逐渐升高，其主要药效成分吡咯里西啶生物碱（ alkaloids, PAs PAs PAs HSOS ）的肝毒性也逐渐被重视。国内外诸多研究进一步明确了 对肝脏的损伤作用，尤其对 所致 的作 用机制、临床表现、自然病程及治疗进行深入阐述，同时亦发现PAs 除可引起HSOS 外，还可通过其二级代谢产物与DNA 所形成络合物激活代谢活化机制，进而诱导肝癌的发生。      [关键词]　药物性肝损伤；吡咯里西啶生物碱；肝窦阻塞综合征；肝癌     [中国图书资料分类号]　R595.3　　　　[文献标志码]　A　　　　[文章编号]  1007-8134(2017)04-0209-04　    　　DOI:10.3969/j.issn.1007-8134.2017.04.006 Research progress of pyrrolizidine alkaloids induced liver injury * WEN Liang-zhi, SUN Wen-jing, LIU Kai-jun, WANG Bin, WEI Yan-ling, CHEN Dong-feng, CUI Hong-li Department of Gastroenterology, Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, Chongqing 400042, China *Corresponding author, E-mail: 2465517206@ 　　[Abstract]　Abuse of traditional Chinese medicine is the most common risk factor of drug-induced liver injury in China. As the “ ” morbidity of hepatic sinusoidal obstruction syndrome caused by Tusanqi is increasing gradually, the hepatotoxicity of pyrrolizidine “ ” alkaloids as the main component of Tusanqi has been paid more attention. In the current studies, the mechanism, clinical manifestation, natural course and therapy of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids have been explored and demonstrated