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Definition Osteoporosis is a systemic skeletal disease characterized by Low bone mass Microarchitectural deterioration of bone tissue, Leading to increased bone fragility And greater susceptibility to fracture Remodeling (骨重建过程) Mechanism of bone remodeling. Hormonal control of bone resorption. Osteoporosis often starts silently and may not be found until a bone fractures. Fragility fracture is a type of pathologic fracture that occurs as result of normal activities, such as a fall from standing height or less ( the National Osteoporosis Foundation ,NOF) 1.5
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