T cell activation激活.pptVIP

T cell activation;; General principles of signal transduction;Protein phosphorylation and dephosphorylation are catalyzed by protein kinase and phosphatase respectively;Protein kinases and protein phosphatases in T activation;;K Y ;;B细胞和T细胞抗原识别受体及相关分子的比较 ; － 带有调控结构域而不显示酶活性； － 可有细胞膜整合蛋白和胞浆蛋白两种形式； － 为大分子复合物的形成提供支架； － 参与细胞活化中胞内信号的整合与传递。; ? T细胞活化连接蛋白 (linker for activation of T cell, LAT): ? 含SH2的白细胞磷酸 化蛋白(SH2-containing leukocyte phospho- protein, SLP-76); ? 生长因子受体结合 蛋白 (growth factor receptor-binding protein, Grb-2）;; The signal of antigen recognition and the signal transduction in T cell;免疫突触的形成使多个TCR-pMHC三元体聚集成簇 ;信号的跨膜传递和转导通路的启动;;K Y ;蛋白酪氨酸磷酸酶CD45 参与Src PTK 的激活 ;;B细胞和T细胞抗原识别受体及相关分子的比较 ; Src family: Lck, Fyn, Lyn, Blk Tyrosine kinase Syk family: ZAP-70, Syk Jak family: Jak1, Jak2, Jak3 Protein kinase Protein kinase C (PKC) Serine/threonine MAP kinase (MAP: mitogen-activation kinase protein) PI 3 kinase (PI: phosphatylinositide) CD45 Tyrosine phos- SHP (SH2-containing phosphatase) phatase SHIP (SH2-containing inosital poly- Protein phosphate 5-phosphatase) phosphatase Serine/threonine Calcineurin 钙调磷酸酶 phosphatase ;;T细胞抗原激活信号转导磷脂酰肌醇途径 的启动 ; Src family: Lck, Fyn, Lyn, Blk