含氟苯酚、烷基环己基苯甲酸和丁烯醛缩二乙醇的合成研究-有机化学专业论文.docx

山东师范大学硕士学位论文确定了反应的最佳工艺条件：在乙醚中，一10～--5C，11(镁粉)：n(烯丙基氯)=1．0：1．0 山东师范大学硕士学位论文 确定了反应的最佳工艺条件：在乙醚中，一10～--5C，11(镁粉)：n(烯丙基氯)=1．0：1．0 反应，制得了烯丙基氯化镁，收率80％：将烯丙基氯化镁与原甲酸---7_,酯按摩尔比1：1 反应，回流6小时，用饱和氯化铵水溶液水解等后处理，蒸除乙醚后，再减压蒸馏，制 备了3一丁烯醛缩二乙醇，收率75．6％，含量98％以1-。产品经元素分析、核磁共振、 红外光谱等进行了确认。 关键词：亲核取代反应、2，4-二氟硝基苯、氟代苯酚、烷基环己基苯、液晶材料中间 体、3一丁烯醛缩二乙醇。 中图分类号：0625．1，0623．541 2 山东师范大学硕士学位论文Abstract 山东师范大学硕士学位论文 Abstract This thesis consists oftwo parts． Part one： At present，since tluorobenzene liquid crystal and cyclohexyl crystal are very popular liquid crystals．some research have done on the synthesis of the intermediate，fluorophenol and alkylcyclohexylbenzene compounds in this thesis． The synthesis of fluorophen01．Fluorophenol，is an important intermediate of liquid crystal， carl also be used in the fields of medicine and pesticides．Some research and analysis on the reaction of 2,4-difluoronitrobenzene and nucleophilic reagent alcohol sodium(methyl alcohol，ethyl alcohol，propyl alcohol，n—butyl alcohol，t-butyl alcohol，et h1)and the reaction choice of opposite—F in different solvent(alcohol，THF,benzene，DMF)and conditions have done in this paper．2-Fluoro一4一nitrophenylmethylether,5-fluoro一2一nitrophenylmethylether and other phenylether are obtained from these reactions．Heating the fluorophenylmethylether in benzene，with A1C13 as the catalyst，fluorophenyl is obtained．The obtmned intermediates and products have been proved by 1HNMR and IR． The synthesis of alkylcyclohexylbenzoic acid：take the synthesis of ethylcyclohexylbenzoic acid as a typical example．With the A1C13 as the catalyst，cis+trans acetylcyclohexylbenzene is synthesized from the reaction of acetyl chloride，cyclohexene and benzene．Then the cis+trans ethylcyclohexylacetophenone is obtained through the reduction of wolf-huangminglong and Frieded-Crafts acylation of cis+trans ethylcyclohexylbenzeng with acetyl chloride；and then trans—ethylcyclohexylacetophenone is got through pufflying；following by oxidizing the trans—ethylcyclohexyl acetophenone，trans—