Road-show-利拉鲁肽幻灯课件.pptVIP

在糖尿病患者中，肠促胰素的效应与健康人群有所不同。左图是正常人口服葡萄糖或静脉推注葡萄糖得到的胰岛素反应。这右图所示的2型糖尿病患者中的情况有明显不同。我们都很清楚，如果我们口服葡萄糖之后，糖尿病患者得到的早相远远低于正常人，而后相有一个高代偿。在静脉推注葡萄糖时患者与正常人的胰岛素分泌情况也不一样。 那么，糖尿病患者中的GLP-1和GIP分泌情况是怎样的呢？ Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Integrated incremental immunoreactive insulin and connecting peptide responses to an oral glucose load of 50 g and an isoglycaemic intravenous glucose infusion, respectively, were measured in 14 Type 2 (non-insulin-dependent) diabetic patients and 8 age- and weight-matched metabolically healthy control subjects. Differences between responses to