大型综合儿童医院门诊患儿超说明书用药情况调查-临床药物治疗杂志.PDFVIP

临床药物治疗杂志 2014 年 3 月第 12 卷第 2 期 Clinical Medication Journal,Mar.2014,Vol.12,No.2 ·药事管理· 大型综合儿童医院门诊患儿超说明书用药情况调查 郭春彦 王晓玲 * 首都医科大学附属北京儿童医院 （北京 10004 5 ） 【摘要】 目的：回顾性调查2012 年4 月～2013 年3 月北京儿童医院门诊患儿超说明书用药情况， 为了解我国儿科超说明书用药现状和制定超说明书用药政策提供证据，促进我国儿科临床合理用药。 方法：随机抽取我院2012 年4 月～2013 年3 月门诊患儿的处方，依据药品说明书，判断其用药医嘱 是否超说明书，分析超说明书用药类型、各年龄段儿童、各类药品超说明书用药情况。结果：共抽取 门诊患儿处方10 716 张，分析处方用药医嘱23 909 条，涉及药品451 种。按处方数、用药医嘱数、 药品总数、基本药物数、非处方药(OTC) 药品数计，超说明书用药发生率分别为53.0%、29.6%、 65.0%、67.0%、79.8%。超说明书用药发生率居前3 位的年龄段为幼儿期（29.8% ）、学龄前期（29.5% ） 和婴儿期 （29.2% ）。超说明书用药类型主要包括无儿童用法用量信息 （61.7% ）、给药频次 （12.8% ） 和剂量 （11.1% ）。结论：我院门诊患儿超说明书用药情况普遍，反映了药品说明书中儿童用药信息 的缺乏，提示国家亟须出台相关政策规范超说明书用药行为，保障儿童用药安全。 【关键词】超说明书用药；儿科；门诊；用药安全 【中图分类号】R95 【文献标志码】B doi:10.3969/j .issn.1672-3384.2014.02.012 A survey of Off-label Drug Use Prescriptions in Outpatient of Beijing Childrens Hospital GUO Chun-yan WANG Xiao-ling. Children ’s Hospital, Capital University of Medical Sciences, Beij ing 100045, China. Abstract Objective: To determine the extent of off-label drug use in outpatient of Beijing 【 】 Childrens Hospital, so as to provide data for getting acquainted with the extent of off-label use in pediatrics in China and developing policy of off-label drug use. Methods: The prescription of outpatient were randomly selected from April 2012 to March 2013, and the off-label use was analyzed according to the package inserts in the following aspects, the types of off-label use in different age groups and categories of medicine. Results: Of the total 10 716 prescriptions with 23 909 medical advices involving 451 drugs were extracted and analyzed, with incidence rates of off-label drug use accounting for 53.0%、 29.6%、65.0%、67.0%、79.8% , respectively. The top 3 age groups with highest incidence rate of off- label drug were infancy(29.8%), pre-school age(29.5%), and babyhood(