Tumor Viruses课件.ppt

RNA Tumor Viruses Viral Oncogene V-onc Cellular Proto-oncogene C-onc 精品文档 RNA Tumor Viruses Proto-oncogene A cellular (host) gene that is homologous with a similar gene that is found in a transforming virus A cellular oncogene can only induce transformation after mutation some other change in the cell’s genome 精品文档 RNA Tumor Viruses Viral RNA genome Reverse transcriptase (Virus-encoded) Viral DNA genome (integrated) DNA-dependent RNA polymerase (Host RNA pol II) Viral genomic RNA Splicing (Host splicing enzymes) messenger RNA viral protein Virus Important: Use HOSTRNA polymerase to make its genome An enzyme that normallymakes mRNA IMPORTANT 精品文档 DNA Tumor Viruses DNA genome mRNA protein virus Host RNA polymerase II Host enzymes OR TRANSFORMATIONIn transformation usually only EARLY functions are expressed 精品文档 DNA Tumor Viruses In Human Cancer Papilloma Viruses cause natural cancers in animals cause benign warts ubiquitous epitheliotropic - most human tumors are malignancies of epithelial cells 精品文档 DNA Tumor Viruses In Human Cancer Papilloma Viruses epidermodysplasia verruciformis wart malignant  squamous cell carcinoma 精品文档 DNA Tumor Viruses In Human Cancer Epidermodysplasia verruciformis Papilloma virus 精品文档 DNA Tumor Viruses In Human Cancer Papilloma Viruses urogenital cancer wart malignant squamous cell carcinoma Papilloma viruses are found in 91% of women with cervical cancer Squamous cell carcinoma: Larynx Esophagus All histologically similar Lung 10% of human cancers may be HPV-linked 精品文档 DNA Tumor Viruses In Human Cancer Papilloma Viruses 51 types identified - most common are types 6 and 11 most cervical, vulvar and penile cancers are ASSOCIATED with types 16 and 18 (70% of penile cancers) EPIDEMIOLOGIAL STUDIES BUT: HPV 16 and HPV 18 do transform human keratinocytes 精品文档 DNA Tumor Viruses In Human Cancer Polyoma Viruses Simian virus 40 - juvenile