舌的发育及其调控机制-中国细胞生物学学报.PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2018, 40(8): 1424–1429 DOI: 10.11844/cjcb.2018.08.0037 舌的发育及其调控机制 李艳 俞姣姣 李浩然 李斐雪* (杭州师范大学生命与环境科学学院, 杭州 310036) 摘要 舌是参与咀嚼、吸允、吞咽、发音等功能的重要器官。舌发育异常会导致无舌、小 舌、舌裂、结舌、巨舌症、腭裂等严重的先天舌发育缺陷疾病。发育完全的舌由肌肉组织、结缔 组织、黏膜组织及血管组成。调控舌发育的基因有Pax3/Pax7 、Dlx基因家族、TGF-β家族和FGF 等, 同时还受Shh与Wnt等信号通路调控。舌发育分子调控机制的研究对相关舌发育畸形疾病的诊 断与治疗有重要意义。 报 关键词 舌; 颅面神经嵴细胞; 鳃弓; 肌原祖细胞; 调控机制 Regulation Mechanisms of Tongue Development 学 Li Yan, Yu Jiaojiao, Li Haoran, Li Feixue* (College of Life and Environmental Science, Hangzhou Normal University, Hangzhou 310036, China) 学 Abstract Tongue is an important organ involved in chewing, swallowing, pronunciation. Abnormal tongue development will lead to aglossia, microglossia, bifid tongue, ankyloglossia, macroglossia and cleft palate. The 物 normal tongue is composed of muscle, connective tissue, mucosal tissue and blood vessels. Paired box gene Pax3 and Pax7, Dlx genes, TGF-β and FGF genes have been proved to be critical for tongue development. Shh and Wnt signaling pathways are also involved in the regulation of tongue development. The study of molecular mechanism 生 will contribute greatly to the diagnosis and treatment of diseases of tongue development. Keywords tongue; cranial neural crest cells; branchial arch; myogenic progenitors; regulation mechanism 胞 在脊椎动物中, 舌由肌肉组织、结缔组织、黏 胀, 形成侧舌隆突。同时, 肌原祖细胞从枕部体节 膜组织及血管组成。舌参与咀嚼、吞咽、发音等生 迁移至舌突, 形成舌部肌肉组织。E11.5侧舌隆突相 理活动, 同时, 也是感知味觉、温度和疼痛的重要器