内镜下氩离子凝术联合雷贝拉唑治疗Barrett食管的疗效分析.docVIP

内镜下氩离子凝固术联合雷贝拉唑治疗Barrett食管的疗效分析 文峰，朱杰伦，黄继征，屈磊，胡海涛（解放军第161医院消化内科，湖北 武汉 430010） [摘要] 目的 探讨内镜下氩离子凝固术联合雷贝拉唑治疗Barrett食管疗效。方法 选择经电子胃镜检查及病理组织学检查确诊为Barrett食管患者181例，随机分成三组，A组（56例）为单纯雷贝拉唑治疗组；B组（60例）为单纯内镜下氩离子凝固术治疗组；C组（65例）为内镜下氩离子凝固术联合雷贝拉唑治疗组。所有入选患者在首次治疗的3、6、12个月内随访复查内镜及病理组织学检查。结果 A、B、C三组在首次治疗的3、6、12个月内随访，A组总有效率分别为5.4%、4.9%、3.1%；B组总有效率分别为85.0%、82.4%、85.4%；C组总有效率分别为90.8%、92.5%、91.5%。以上两两组间比较均有统计学意义（P0.05）。结论 内镜下氩离子凝固术联合雷贝拉唑治疗Barrett食管是安全有效的，值得临床推广与应用。 [关键词] Barrett食管；内镜下氩离子凝固术；雷贝拉唑；治疗 [中图分类号] R571 [文献标识码] A [文章编号] 1672-5042（2011）03-0000-00 [作者简介] 文峰（1977-），男，湖北省罗田县人，主治医师，本科，主要从事消化内科疾病临床方面的研究。电话：（027[收稿日期] 2011-01-17 [修回日期] Clinical analysis of argon plasma coagulation combined with Rabeprazole for Barrett’s esophagus WEN Feng,ZHU Jie-lun,HUANG Ji-zheng,QU Lei,HU Hai-tao (Department of Gastroenterology,161st Hospital of PLA,Wuhan Hubei 430010,China) Abstract: Objective To study the effects of argon plasma coagulation combined with Rabeprazole on Barrett’s esophagus.Methods Totally 181 patients with Barrett’s esophagus diagnosed by endoscope and pathological method were randomized into 3 groups:group A (n=56) were treated with Rabeprazole;group B (n=60) were treated with argon plasma coagulation and group C (n=65) were treated with argon plasma coagulation combined with Rabeprazole.All the patients were rechecked by endoscope and pathological method within 3,6 and 12 month after treatment.Results The follow-up went within 3,6 and 12 month after the first treatment.The total effective rates in group A were 5.4%,4.9%,3.1% respectively;those of group B were 85.0%,82.4%,85.4% respectively and those of C were 90.8%,92.5%,91.5% respectively.There were statistical differences between groups(P0.05).Conclusion Argon plasma coagulation combined with Rabeprazole in the treatment of Barrett’s esophagus is effective and safe and is worth applying and extending in clinics. Keywords: Barrett esophagus;argon plasma coagulation;Rabeprazole;treatment Barrett食管（Barrett esophagus，BE）