神经保护剂及脑卒中的治疗策略.pptVIP

缺血/再灌注使自由基产生增加 神经细胞 胶质细胞 内皮细胞 Stroke. 2004;35:1449-1453 SAINT I outcomes 1.20 (1.01-1.42) mRS Subgroup interactions with primary endpoint not significant Treatment-time p=0.92 Treatment-age p=0.62 Treatment-severity p=0.72 Treatment-alteplase p=0.93 Treatment-diabetes p=0.98 Treatment-glucose p=0.27 etc Safety: ICH after thrombolysis Asympt ICH Sympt ICH 20.9% P0.005 SAINT-I结论 The administration of NXY-059 within six hours after the onset of acute ischemic stroke significantly improved the primary outcome (reduced disability at 90 days), but it did not significantly improve other outcome m