病理学绪论病理学图片Introduction.pptVIP

Pathology Second Edition Editor in chief: CHEN Jie and LI Gandi People’s Medical Publishing House Textbook Introduction to pathology  Peking Union Medical College Chen Jie Introduction to pathology A bridging discipline involving both basic science and clinical practice. Devoted to the study of the structural and functional changes in cells, tissues and organs that underlie disease. To explain the whys and wherefores of the signs and symptoms of the patients. Providing a sound foundation for rational clinical care and therapy. Pathology The study of etiology of the disease The study of pathogenesis of disease The study of morphological changes of disease The most important diagnosis in modern medical practice The important step in evidence-based medicine The functional consequences of the morphologic changes (clinical significance) Pathology Biopsy Histopathology Cytology Electromicroscopy Resected specimens Histochemistry Autopsy Microbiology Cell tissue culture immunohistochemistry Molecular pathology Etiology Intrinsic or genetic Acquired infectious nutritional chemical physical Pathogenesis Initial stimulus -------- ultimate expression of disease Defective gene -------- cysts and fibrosis Morphologic changes Structural alterations cells tissues organs Characteristic of the disease Diagnostic of the etiologic process Clinical significance Functional abnormality Clinical features (symptoms and signs) Clinical course Prognosis of the disease “As is our pathology, so is our medicine”“病理为医之本” Sir William Osler 1849-1919 基础医学课目中与临床最接近的当推病理学，因为它是临床与基础之间的桥梁，要学好临床先要学好病理学，我毕业后才认识这个道理。原想加学一年病理学以资祢补，可是没能做到，至今引为遗憾。 —— 著名医学家张孝骞 谢 谢