氟唑菌酰胺的合成与生物活性-现代农药.PDF

第16 卷 第4 期 现代农药 Vol.16 No.4 2017 年8 月 Modern Agrochemicals Aug. 2017 ◆ 研究与开发 ◆ 氟唑菌酰胺的合成与生物活性 王 刚，吕 亮，刘吉永，单中刚，杨辉斌，李 斌* （ 沈阳中化农药化工研发有限公司，新农药创制与开发国家重点实验室，沈阳 110021） 摘要：氟唑菌酰胺是巴斯夫公司开发的吡唑酰胺类杀菌剂。本文以二氟乙酰乙酸乙酯、原甲酸三 1 乙酯和甲基肼等为起始原料经 反应合成了氟唑菌酰胺， 目标化合物的结构经 证。 杀 6步 H NMR确 菌活性测试结果表明：氟唑菌酰胺对水稻纹枯病、黄瓜白粉病、大豆锈病具有优异的活性。 关键词：氟唑菌酰胺；合成；杀菌活性 中图分类号： ＋ ＋ 文献标志码： ： TQ 455.4 7 ；TQ 450.2 1 A doi 10.3969/j.issn.1671-5284.2017.04.003 Synthesis and Bioactivity of Fluxapyroxad WANG Gang, LV Liang, LIU Ji-yong, SHAN Zhong-gang, YANG Hui-bin, LI Bin* （State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals Research and Development Co., Ltd., Shenyang 110021, China ） Abstract: Fluxapyroxad was a novel pyrazole-carboxamide fungicide which developed by BASF Corporation. Fluxapyroxad was synthesized by using ethyl difluoroacetoacetate, triethoxy orthoformate and methylhydrazine as starting 1 NMR. The results of fungicidal activity at greenhouse materials. The structure of the target compound was confirmed by H showed that fluxapyroxad had excellent fungicidal activities against rice sheath blight, cucumber powdery mildew and soybean rust. Key words: fluxapyroxad; synthesis; fungicidal activity SDHI （succinate dehydrogenase inhibitors）