阿扎胞苷-技术总结(共2篇).docxVIP

阿扎胞苷-技术总结(共2篇) 　　AcOHNOHNNNSiOAcNH2SiMol.Wt.:　　NNMol.Wt.:　　2ONHMol.Wt.:Wt.:　　NH2NNN　　NaOMeNAcOHOMe　　3　　Mol.Wt.:Wt.:　　步骤1操作程序：　　Ina22L,3-neckedflask,amixtureof5-azacytosine(1)(kg,mol,molareq.),HMDS(kg)andammoniumsulfate(g)washeatedatrefluxfor2hours.Afreshamountofammoniumsulfate(g)wasadded,andtherefluxwascontinuedfor6hourslonger.Theinitialslurryturnedintoaclear,pale-yellow,solutionandnomoregasevolvedattheendofthereflux.TheexcessHMDSwasevaporatedoffinvacuumtoobtainanoff-whiteresidue,whichistrimethylsilylated5-azacytosine.　　步骤2操作程序：　　Trimethylsilylated5-azacytosine(6)preparedaccordingt