土霉素的生产工艺毕业论文.doc

毕业论文 土霉素的生产工艺 目的：土霉素生产工艺的概述。 摘要：土霉素提取工艺是通过黄血盐-硫酸锌作净化剂协同去除 蛋白质等高分子杂质，然后用122-2树脂脱色进一步净化土霉素滤液， 最后调pH至4.8左右结晶得到土霉素碱产品。 关键词：生产工艺；土霉素；黄血盐-硫酸锌 目 录 1 文献综述·················································4 1.1 霉素简介·····················································5 1.1.1 名称与化学结构式 ············································5 1.1.2 性状与理化质 ················································6 1.2 土霉素生产菌种···············································6 2 土霉素生产工艺·······················7 土霉素的生产工艺流程概述····································7 2.2 发酵工艺流程················································7 2.2.1 斜面孢子制备················································7 2.2.2 一级种子罐发酵··············································7 2.2.3 二级种子罐发酵··············································7 2.2.4 三级发酵罐发酵··············································8 2.3 酸化过滤工艺流程············································9 2.3.1 酸化························································9 2.3.1.2发酵液的纯化···············································10 2.3.2 过滤·······················································10 2.4 脱色结晶工艺流程············································11 2.4.1 脱色························································11 2.4.2 结晶························································11 2.5.1 离心·······················································13 2.5.2 干燥·······················································13 2.5.2.1湿成品干燥记录·············································13 3 土霉素生产的废水处理····················13 3.2 该生产废水处理方案··········································14 3.2.1 高压脉冲电凝水处理技术进行预处理····························14 3.2.2 复合絮凝(气浮)技术降低抗生素残余效价························15 3.2.3 组合兼氧技术进行水解酸化····································15 3.2.4 生物活性炭滤池进行深度处理··································16 3.3 生产废水处理设备及参数······································17 4土霉素的微生物限度检验方法 ···························18 4.1 材料 ···············································