汕头大学医学院药理学精品课程 Drugs of Anti-Parkinson’s disease.pptVIP

Drugs of Anti-Parkinson’s disease Department of Pharmacology Zhang Yan-mei Pathogenesis of Parkinson’s disease Parkinson’s disease (PD) is a progressive disorder of movement that occurs mainly in the elderly. The chief symptoms are: Tremor at rest, usually starting in the hands (‘pill- rolling’ tremor), which tend to diminish during voluntary activity Pathogenesis of Parkinson’s disease Muscle rigidity, detectable as an increased resistance in passive limb movement --Bradykinesia Suppression of voluntary movements (hypokinesis), due partly to an inherent inertia of the motor system, which m